Autophagy and Tumorigenesis
نویسندگان
چکیده
منابع مشابه
PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis
Autophagy plays a critical role in the progression of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Protein tyrosine phosphatase receptor type O (PTPRO) was recently identified as a tumor suppressor, but little is known about its role in NASH. Here, we investigated the role of PTPRO-dependent autophagy in insulin resistance, lipid metabolism, and hepatocarcinogenesis. ...
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Reactive oxygen species (ROS) at physiological levels are important cell signaling molecules. However, aberrantly high ROS are intimately associated with disease and commonly observed in cancer. Mitochondria are primary sources of intracellular ROS, and their maintenance is essential to cellular health. Autophagy, an evolutionarily conserved process whereby cytoplasmic components are delivered ...
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ژورنال
عنوان ژورنال: Seminars in Immunopathology
سال: 2010
ISSN: 1863-2297,1863-2300
DOI: 10.1007/s00281-010-0213-0